Authorities say at least four people are dead and several others injured after suspected tornadoes swept through southwestern Michigan.
In Branch County, the sheriff said a suspected tornado in the Union Lake area left three people dead and at least 12 people injured, including three who were hospitalized.
In Cass County, local officials said one person died and several other were injured after a suspected tornado touched down near Edwardsburg late Friday afternoon.
Multiple homes and barns "sustained damage ranging from major structural impacts to complete destruction," according to a news release from the county.
The National Weather Service issued tornado warnings for the region Friday afternoon.
The devastation comes as nearly 70 million Americans are under a severe weather threat heading into the weekend, with tornado watches issued for multiple states, after deadly storms swept through Oklahoma.
Michigan Gov. Gretchen Whitmer said Friday the state is coordinating an "all-hands-on-deck response to severe weather in southwestern Michigan."
The National Weather Service issued tornado warnings for parts of southern Michigan on Friday afternoon, including for a large and "extremely dangerous" tornado south of Kalamazoo.
There were multiple reports of "significant damage" in Three Rivers, according to the National Weather Service. Union City also saw "significant storm damage" on Friday, according to local officials.
The storm system is bringing severe weather from the Rockies to the Upper Midwest and across much of the Plains on Friday.
The severe storm threat stretches from Dallas to Milwaukee, including Des Moines, Iowa, St. Louis and Oklahoma City. Strong winds, hail, and brief tornadoes are all possible.
A large area stretching from far northeast Texas to southwest Iowa is under an enhanced threat, with tornadoes and very large hail as the main concerns.
The greatest tornado threat on Friday is from far northeastern Texas to just south of Springfield, Missouri. Tornado watches are in effect across six states into Friday night -- Texas, Oklahoma, Kansas, Nebraska, Missouri and Iowa.
Heavy downpours, especially in Texas, Oklahoma, Arkansas and Missouri, could also result in localized flash flooding.
The governor of Missouri declared a state of emergency on Friday "in preparation for potentially dangerous severe weather forecasted across the state," including the threat of damaging winds, large hail and tornadoes, his office said.
The threat comes after seven reported tornadoes and golf ball-sized hail impacted parts of west Texas and Oklahoma. A mother and daughter were killed in Major County, Oklahoma, on Thursday night after severe weather swept through the area, according to Oklahoma Gov. Kevin Stitt. They were found dead in a vehicle that appeared to have tornado damage, authorities told ABC Oklahoma City affiliate KOCO.
Elsewhere, winter weather advisories are also in effect Friday from Colorado to Minnesota for the cold side of the storm with snow and ice. Denver could see 2 to 4 inches of snow.
Icy conditions are expected across parts of the Dakotas, Nebraska and Minnesota, with heavy rain forecast to move through the upper Midwest through Friday night.
To the South, widespread severe weather is possible through late Friday from Texas to Wisconsin.